Meningococcal infection.

Studies on Meningococcal Infection

From meningococcus Type II broth autolysates, a substance, corresponding to the protective antibody has been isolated. This substance, termed kappa substance, is firmly connected with protein but can be separated by the action of proteolytic enzymes. Methods of preparation and purification are given, together with chemical and serological data. In whole cells from young cultures, this substance...

Treatment of meningococcal infection.

Aggressive early treatment of meningococcal disease can reduce mortality. This relies on prompt recognition and treatment of the complications of septicaemia and meningitis, appropriate ongoing intensive care where necessary, and adequate management of multiple organ failure. Most children with meningococcal disease survive intact, but long term sequelae are increasingly recognised and make fol...

Meningococcal infection and proteolytic control.

Cascade enzyme inhibitors (C1-esterase inhibitor, C3b inactivator, antithrombin III) and other major proteolytic enzyme inhibitors (alpha 1 trypsin inhibitor, alpha 1 chymotrypsin inhibitor, inter-alpha-trypsin inhibitor, alpha 2 macroglobulin) as well as C3 and alpha 1 acid glycoprotein, have been examined in the sera of Nigerian patients suffering from meningococcal infection of varied severi...

Meningococcal Toxæmia Accompanying Malarial Infection

Disseminated intravascular coagulation in meningococcal infection.

Coagulation in Meningococcal Infection Sir, The description by Fox in the recent issue of the Archives (October 1971) of histological evidence of widespread intravascular coagulation in 13 patients dying of the Waterhouse-Friderichsen syndrome (with proved meningococcal septicaemia in two) and his suggestion that heparin should be used in such patients, prompts us to report the following patient:-